Publications

2016

Potvin-Trottier, L., Lord, N. D., Vinnicombe, G., & Paulsson, J. (2016). Synchronous long-term oscillations in a synthetic gene circuit. Nature, 538, 514–517

Okumus B, Landgraf D, Lai GC, Bakhsi S, Arias-Castro JC, Yildiz S, Huh D, Fernandez-Lopez R, Peterson CN, Toprak E, El Karoui M, Paulsson J. (2016) Mechanical slowing-down of cytoplasmic diffusion allows in vivo counting of proteins in individual cells. Nat. Commun. 18, 11641.

Hilfinger A,  Norman, TM,  Paulsson J. (2016). Exploiting natural fluctuations to identify kinetic mechanisms in sparsely characterized system. Cell Systems, 2 (4), 251-259

Uphoff S., Lord N.D., Potvin-Trottier L., Okumus B., Sherratt D.J., Paulsson J., (2016) Stochastic activation of a DNA damage response causes cell-to-cell mutation rate variation. Science 351, 6277, 1094-1097

Hilfinger A, Norman, TM, Vinnicombe, G, Paulsson J. (2016). Constraints on Fluctuations in Sparsely Characterized Biological Systems. Phys. Rev. Lett.. 116, 058101.

Jajoo, R., Jung, Y., Huh, D., Viana, M. P., Rafelski, S. M., Springer, M., & Paulsson, J. (2016). Accurate concentration control of mitochondria and nucleoids. Science351(6269), 169–172. PMID: 26744405

Ke N, Landgraf D, Paulsson J, Berkmen M.. (2016). Visualization of periplasmic and cytoplasmic proteins with a self-labeling protein tag. Journal of Bacteriology.  00864-15 . PMID: 26787765

2015
Hilfinger A, Paulsson J. (2015). Systems biology: Defiant daughters and coordinated cousins. Nature. 519 (7544): 422-3. PMID: 25762142.

Norman, TM, Lord, ND, Paulsson, J & Losick, R. (2015). Stochastic Switching of Cell Fate in Microbes. Annual Review of Microbiology.  69: 381-403 . PMID: 26332088

2014
Taheri-Araghi S, Bradde S, Sauls JT, Hill NS, Levin PA, Paulsson J, Vergassola M, Jun S. (2014). Cell-size control and homeostasis in bacteria. Curr Biol. 25 (3): 385-91. PMCID: PMC4323405

2013
Norman, TM, Lord, ND, Paulsson, J & Losick, R. (2013). Memory and modularity in cell-fate decision making. Nature. 503 (7477): 481-6. PMCID: PMC4019345

Lau, B.T., Malkus, P. & Paulsson, J. (2013). New quantitative methods for measuring plasmid loss rates reveal unexpected stability. Plasmid, 70(3):353-61. PMCID: PMC3966108.

Toprak, E., Veres, A., Yildiz, S., Pedraza, J.M., Chait, R., Paulsson, J. & Kishony, R. (2013). Building a morbidostat: an automated continuous-culture device for studying bacterial drug resistance under dynamically sustained drug inhibition. Nat Protoc., 8 (3): 555-67. PMCID: PMC3708598.

2012
Hilfinger, A., Chen, M. & Paulsson, J. (2012). Using temporal correlations and full distributions to separate intrinsic and extrinsic fluctuations in biological systems. Phys Rev Lett., 109(24):248104. PMCID: PMC3697929.

Landgraf, D., Okumus, B., Chien, P., Baker, T.A. & Paulsson, J. (2012). Segregation of molecules at cell division reveals native protein localization. Nat Methods, 8;9(5):480-2. PMCID: PMC3779060.

Tal, S. & Paulsson, J. (2012). Evaluating quantitative methods for measuring plasmid copy numbers in single cells. Plasmid, 67(2):167-73. PMCID: PMC3709585.

2011
Huh, D. & Paulsson, J. (2011). Random partitioning of molecules at cell division. Proc Natl Acad Sci USA., 108(36):15004-9. PMCID: PMC3169110.

Hilfinger, A. & Paulsson, J. (2011). Separating intrinsic from extrinsic fluctuations in dynamic biological systems. Proc Natl Acad Sci USA., 108(29):12167-72. PMCID: PMC3141918.

Huh, D. & Paulsson, J. (2011). Non-genetic heterogeneity from stochastic partitioning at cell division. Nat Genet., 43(2):95-100. PMCID: PMC3208402.

2010
Lestas, I., Vinnicombe, G. & Paulsson J. (2010). Fundamental limits on the suppression of molecular fluctuations. Nature, 467(7312):174-8. PMCID: PMC2996232.

2008
Pedraza, J.M. & Paulsson, J. (2008). Effects of molecular memory and bursting on fluctuations in gene expression. Science, 319(5861):339-43.

Lestas, I., Paulsson, J., Ross, N.E. & Vinnicombe, G. (2008). Noise in gene regulatory networks. IEEE transactions on automatic control, Regular Papers (Special Issue on Systems Biology):189-200.

2007
Pedraza, J.M. & Paulsson, J. (2007). Random timing in signaling cascades. Mol Syst Biol., 3:81. PMCID: PMC1828750.

2006
Rando, O.J. & Paulsson, J. (2006). Noisy silencing of chromatin. Dev Cell., 11(2):134-6.

Paulsson, J. & Chattoraj, D.K. (2006). Origin inactivation in bacterial DNA replication control. Mol Microbiol., 61(1):9-15.

Bar-Even, A., Paulsson, J., Maheshri, N., Carmi, M., O'Shea, E., Pilpel, Y. & Barkai, N. (2006). Noise in protein expression scales with natural protein abundance. Nat Genet., 38(6):636-43.

Springer, M. & Paulsson, J. (2006). Biological physics: harmonies from noise. Nature, 439(7072):27-8.

2005
Golding, I., Paulsson, J., Zawilski, S.M. & Cox, E.C. (2005). Real-time kinetics of gene activity in individual bacteria. Cell, 123(6):1025-36.

Paulsson, J. (2005). Prime movers of noisy gene expression. Nat Genet., 37(9):925-6.

Paulsson, J. (2005). Models of Stochastic Gene Expression. Phys. Life Rev., 2:157-175.

Das, N., Valjavec-Gratian, M., Basuray, A.N., Fekete, R.A., Papp, P.P., Paulsson, J. & Chattoraj, D.K. (2005). Multiple homeostatic mechanisms in the control of P1 plasmid replication. Proc Natl Acad Sci USA., 102(8):2856-61. PMCID: PMC549481.

2004
Paulsson, J. (2004). Summing up the noise in gene networks. Nature, 427(6973):415-8.

Olsson, J.A., Paulsson, J. & Nordström, K. (2004). Effect of the CopB auxiliary replication control system on stability of maintenance of Par(+) plasmid R1. J. Bacteriol., 186(1):207-11. PMCID: PMC303431.

2003
Elf, J., Paulsson, J., Berg, O.G. & Ehrenberg M. (2003). Near-critical phenomena in intracellular metabolite pools. Biophys J., 84(1):154-70. PMCID: PMC1302600.

2002
Paulsson, J. (2002). Multileveled selection on plasmid replication. Genetics, 161(4):1373-84. PMCID: PMC1462198.

2001
Park, K., Han, E., Paulsson, J. & Chattoraj, D.K. (2001). Origin pairing ('handcuffing') as a mode of negative control of P1 plasmid copy number. EMBO J., 20(24):7323-32. PMCID: PMC125786.

Paulsson, J. & Ehrenberg, M. (2001). Noise in a minimal regulatory network: plasmid copy number control. Q Rev Biophys., 34(1):1-59.

2000
Berg, O.G., Paulsson, J. & Ehrenberg, M. (2000). Fluctuations in repressor control: thermodynamic constraints on stochastic focusing. Biophys J., 79(6):2944-53. PMCID: PMC1301173.

Berg, O.G., Paulsson, J. & Ehrenberg, M. (2000). Fluctuations and quality of control in biological cells: zero-order ultrasensitivity reinvestigated. Biophys J., 79(3):1228-36. PMCID: PMC1301019.

Paulsson, J., Berg, O.G. & Ehrenberg, M. (2000). Stochastic focusing: fluctuation-enhanced sensitivity of intracellular regulation. Proc Natl Acad Sci USA., 97(13):7148-53. PMCID: PMC16514.

Paulsson, J. & Ehrenberg, M. (2000). Random signal fluctuations can reduce random fluctuations in regulated components of chemical regulatory networks. Phys Rev Lett., 84(23):5447-50.

Paulsson, J. & Ehrenberg, M. (2000). Molecular clocks reduce plasmid loss rates: the R1 case. J Mol Biol., 297(1):179-92.

1998
Paulsson, J. & Ehrenberg, M. (1998). Trade-off between segregational stability and metabolic burden: a mathematical model of plasmid ColE1 replication control. J Mol Biol., 279(1):73-88.

Paulsson, J. Nordström, K. & Ehrenberg, M. (1998). Requirements for rapid plasmid ColE1 copy number adjustments: a mathematical model of inhibition modes and RNA turnover rates. Plasmid, 39(3):215-34.

 

Nature 20163.27 MB