#  Daniel Eaton 

Graduate Student

 

 

 



   ![Daniel](/sites/g/files/omnuum11536/files/styles/hwp_4_5__320x400/public/paulsson/files/daniel.jpg?itok=eHEc1xul) 

 



 





 

I investigate how bacterial cells integrate internal and external signals to regulate growth, gene expression, and cell physiology.

I am particularly focused on understanding how perturbation of different essential genes impacts phenotypic outcomes such as cell growth rate and size, at a systematic whole-genome level.

Key questions that guide my research include:

How do internal perturbations in gene expression affect cell physiology - especially in terms of growth rate and morphology - and how can this be leveraged to understand gene function?

Can we use changes in physiology to identify broad classes of functionally related genes as well as annotate genes of unknown function?

Do physiological scaling rules encode information about regulation? Can these rules be uncovered systematically?

To address these questions, I developed high-throughput methods enabling systematic image-based measurement and analysis of complex genotype-to-phenotype relationships at massive scale and resolution.

Currently we are applying these methods to systematic gene perturbation libraries, libraries of cell circuits, and genetic reporter libraries.



 

 

 





 

 

- ## Role
    
     [Alumni](/role/alumni)