@article {323446,
	title = {Random signal fluctuations can reduce random fluctuations in regulated components of chemical regulatory networks.},
	journal = {Physical Review Letters},
	volume = {84},
	number = {23},
	year = {2000},
	month = {2000 Jun 5},
	pages = {5447-50},
	abstract = {Many intracellular components are present in low copy numbers per cell and subject to feedback control. We use chemical master equations to analyze a negative feedback system where species X and S regulate each other{\textquoteright}s synthesis with standard intracellular kinetics. For a given number of X-molecules, S-variation can be significant. We show that this signal noise does not necessarily increase X-variation as previously thought but, surprisingly, can be necessary to reduce it below a Poissonian limit. The principle resembles Stochastic Resonance in that signal noise improves signal detection.},
	keywords = {DNA Replication, Feedback, Gene Dosage, Gene Expression Regulation, Bacterial, Kinetics, Models, Theoretical, Plasmids, Statistical Distributions, Stochastic Processes},
	issn = {0031-9007},
	author = {Paulsson, J and Ehrenberg, M}
}
