%0 Journal Article %J Physical Review Letters %D 2000 %T Random signal fluctuations can reduce random fluctuations in regulated components of chemical regulatory networks. %A Paulsson, J %A Ehrenberg, M %K DNA Replication %K Feedback %K Gene Dosage %K Gene Expression Regulation, Bacterial %K Kinetics %K Models, Theoretical %K Plasmids %K Statistical Distributions %K Stochastic Processes %X Many intracellular components are present in low copy numbers per cell and subject to feedback control. We use chemical master equations to analyze a negative feedback system where species X and S regulate each other's synthesis with standard intracellular kinetics. For a given number of X-molecules, S-variation can be significant. We show that this signal noise does not necessarily increase X-variation as previously thought but, surprisingly, can be necessary to reduce it below a Poissonian limit. The principle resembles Stochastic Resonance in that signal noise improves signal detection. %B Physical Review Letters %V 84 %P 5447-50 %8 2000 Jun 5 %G eng %N 23 %1 http://www.ncbi.nlm.nih.gov/pubmed/10990965?dopt=Abstract