Noisy silencing of chromatin.
Publication information:
Rando, O. J.; Paulsson, J.
Noisy Silencing of Chromatin. Developmental Cell 2006, 11 (2), 134-6. https://doi.org/10.1016/j.devcel.2006.07.012.
Abstract
Chromatin-based repression is a major mechanism for epigenetically heritable variation. Work in the July 21 issue of Molecular Cell quantitatively examines transcriptional silencing in individual yeast cells, demonstrating locus-specific effects and finding that different silencing mutants exhibit qualitatively distinct single-cell defects.